J Thorac Dis. The endoplasmic reticulum (ER) is the cellular site for protein folding. With the aging of the hepatitis C virus (HCV)-infected patient cohort and the availability of highly effective and tolerable treatment regimens, an increasing number of elderly patients are now eligible for HCV therapy. The importance of alcohol and cannabis consumption for the effectiveness of treatment of chronic hepatitis C virus (HCV) infection with direct acting antivirals (DAAs) in people on opioid substitution therapy (OST) has not been investigated in detail. What We Do. However, patients with impaired kidney function have been excluded from several clinical trials. He died on 4 May 1847, in his hometown, at the age of 71. The patients will be screened at home for 1 night with the ApneaLink device by ResMed. The introduction of direct-acting antivirals (DAA) has led to an increase in sustained virologic response rates (SVR), but is accompanied by higher treatment costs... Background: While acute ER stress is lethal, chronic sub-lethal ER stress causes cells to adapt b... Responder operator curves for prediction of failure to clear virus on therapy based on clinical and genotyping data. Join Facebook to connect with Tobias Müller and others you may know. eCollection 2019. , and HCV-related hepatocellular carcinoma development, considering the SCCS as case-control study. Spart euch bei eurer Abishirtbestellung bis zum 31.01.2018 die Versandkosten! We are constantly updating our comprehensive database of fund managers and their career history. Hardware Boards. Hepatocellular adenomas: is there additional value in using Gd-EOB-enhanced MRI for subtype differentiation? , Madan K, Biswal SK, Tiwari P, Mittal S, Hadda V, Mohan A, Khilnani GC, Guleria R. Lung India. Tobias Müller is an e-mobility expert with a long background in the fields of automotive engineering and development processes. The importance of three IL28B single nucleotide polymorphisms (rs8099917, rs12980275 and rs12979860) for HCV genotype 2/3-infected patients is unknown. However, there are little data on the efficacy and safety of this approach, or on the consumption of sedative drugs and lidocaine during nebulized administration. If you are (or represent) Tobias Mueller and would like to update or provide biographical information for this factsheet please email manager-research@citywire.co.uk. In patients with chronic hepatitis C virus (HCV) infection, several variants of the interleukin-28B (IL28B) gene have been shown to correlate significantly with a sustained virologic response (SVR). Respiration. Nebulized lidocaine for flexible bronchoscopy: a randomized, double-blind, placebo-controlled trial. Please enable it to take advantage of the complete set of features! We retrospectively identified 104 consecutive patients (75 males; mean age 41.98 ± 12.5 years) with confirmed diagnosis of PSC who underwent 227 gadoxetic acid... Zusammenfassung IL28B polymorphisms strongly predict spontaneous and treatment-induced clearance of hepatitis C virus (HCV) infection. Accessibility Laszlo has 9 jobs listed on their profile. The aim of the present study was to investigate the prevalence of five well-characterized specific single nucleo... Background The urgent need in HCV-infected patients with liver disease mandated the rapid implementation of IFN-free DAA combination therapies following their regulatory approval in 2014 and 2015 without full knowledge of the optimal combinations and regimens. We investigated sustained virological response (SVR) rates and proportion of l... DHCR_OST-Cannabis_Alcohol_supplementary_2018-10-30_xyz151015746ed84_3-converted – Supplemental material for Alcohol and Cannabis Consumption Does Not Diminish Cure Rates in a Real-World Cohort of Chronic Hepatitis C Virus Infected Patients on Opioid Substitution Therapy—Data From the German Hepatitis C-Registry (DHC-R). 2013 Sep;30(6):587-9. doi: 10.1177/1049909112458577. This Article explores whether the revision of the ICC Rules has advanced the process. GC Tobias Müller, Pia Andrée WertheimerAktualisiert vor 8 MinutenIdylle zwischen Felsflanken: Der Fählensee. About Us. 2016;92:266â73. Cyclophilin A (CypA) is required for viral replication, and CypA inhibitors are in development. (DOC), HLA-C (two-digit genotyping) in SVR and NSVR. The purpose of our study was to investigate how to differentiate between Gd-EOB-enhancing HCAs and focal nodular hyperplasias (FNHs). The expression of (a) phospho-IRE1, total IRE1, phospho- eIF2α and total eIF2α an... JFH1 HCV fully infective cell system: (a) Titration of viral infection was done and TCID50 was calculated as described in the methods. 2019 Jul;36(Supplement):S37-S89. Ich bin freier Journalist und als solcher bemüht, viel unterwegs zu sein, sei es in China, Mexiko, den USA oder Österreich. They were the parents of at least 1 daughter. Due to our privacy policy, only current members can send messages to people on ResearchGate. AASLD/IDSA treatment guidelines for hepatitis C virus (HCV) infection state that testing for quantitative HCV RNA can be considered at the end of antiviral treatment (EOT) with interferon‐free regimens. At the centre of the experience, however, is the performance itself, which may be enhanced on an aural, visual or even tactile level. Clipboard, Search History, and several other advanced features are temporarily unavailable. Determination of the SAS- frequence in patients with bronchial carcinoma. Stylishe Textilien findet ihr bei uns auf www.freieform.de Critical Examination of a Peculiar Laboratory Observation âDownload apps by Tobias Mueller, including AquaNautic Pro. (DOC), Odds ratios and corresponding p-values for predicting failure of SVR using logistic regression models. Here, we studied whether the PNPLA3 rs738409 polymorphism also affects predisposition to hepatocellular carcinoma (HCC). Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis. Individualization of interferon alfa-based therapies based on a combination o... Background: Elevated IgG4 levels have been reported among patients with primary sclerosing cholangitis. Epub 2012 Sep 9. Foto: Appenzellerland TourismusWer in diesen speziellen Zeiten abschalten und dem Alltagsstress entfliehen möchte, der sollte einfach ⦠Endobronchial administration of lidocaine during bronchoscopy via nebulizer was found to be well tolerated and safe and was associated with reduced lidocaine and fentanyl dosages compared to administration via syringe. To determine if gene variants in the TRAIL receptor I (DR4) gene affect the risk of hepatitis C virus (HCV)-induced liver cancer (HCC), we analysed DR4 mutations C626G (rs20575) and A683C (rs20576) in HCV-infected patients wi... CXCL1 is a ligand for CXC chemokine-receptor 2 expressed on hepatic stellate cells (HSC). of Infectious Diseases, Department of Internal Medicine II, Division of Hepatology, Real-World Clinical Management of Patients with Primary Biliary Cholangitis—A Retrospective Multicenter Study from Germany, Gadoxetic acid-enhanced MRI in primary sclerosing cholangitis: added value in assessing liver function and monitoring disease progression, Veränderungen der Hepatitis-C-Virus-Genotyp-1a/1b-Verteilung zwischen 2004 und 2018 in Deutschland – eine Analyse von 17093 Patienten aus verschiedenen Real-World-Registern, HBP-enhancing hepatocellular adenomas and how to discriminate them from FNH in Gd-EOB MRI, Genetic variants of interleukin 1 beta are associated with viral hepatitis-related HCC in Caucasian patients, Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity, Clinical and molecular characterization of the human kidney as extrahepatic site of hepatitis E virus infection, Gender disparity in the association of interleukin-10 and interleukin-12 polymorphisms with the progression of hepatitis B virus infection in Caucasians, Evolution of hepatitis C virus genotype 1a vs 1b distribution reflects profound changes in HCV epidemiology in Germany - analysis of 17,093 patients from five consecutive registries including the German hepatitis C-registry (DHC-R), Geschlechtsabhängige Assoziation von genetischen Varianten von Interleukin 10 und 12 mit dem Verlauf der Hepatitis-B-Virus-Infektion bei kaukasischen Patienten, Evolution of hepatitis C virus genotype 1a vs. 1b distribution reflects profound changes of HCV epidemiology in Germany between 2004 and 2018 - Analysis of 17,093 patients from five consecutive registries including the German Hepatitis C-Registry (DHC-R), Assoziation von rs16944 im Interleukin-1-beta-Gen mit der Entwicklung eines hepatozellulären Karzinoms in kaukasischen Patienten mit chronischer Virushepatitis, Ten‐year follow‐up of a randomized controlled clinical trial in chronic hepatitis delta, Treatment outcomes in hepatitis C virus genotype 1a infected patients with and without baseline NS5A resistance‐associated substitutions, Sofosbuvir monotherapy fails to achieve HEV RNA elimination in patients with chronic hepatitis E – The HepNet SofE pilot study, Resistance‐associated substitutions in patients with chronic hepatitis C virus genotype 4 infection. Background: Clinical practice guidelines for patients with primary biliary cholangitis (PBC) have been recently revised and implemented for well-established response criteria to standard first-line ursodeoxycholic acid (UDCA) therapy at 12 months after treatment initiation for the early identification of high-risk patients with inadequate treatment... Purpose: A common polymorphism in the neurocan (NCAN) gene, which is known to be expressed in neuronal tissue, has been identified as a risk factor for non-alcoholic fatty liver disease (NAFLD). Ideally, insights gained from my studies will facilitate the development of specific or broad-spectrum therapeutics against clinically relevant viruses. Das Murmeltier ist, ganz seinem Lebensraum angepasst, ein zäher Hund â bzw., zoologisch korrekter, ein zähes Erdhörnchen, wenn es zu kurz oder zu kalt gegart wird. DHCR7 View the profiles of people named Tobias Müller. Objectives: It is well established that polymorphisms in host genes, especially in components of the innate immune response, contribute to the phenom... Background & aims: , and To explore the role of CHOP in hepatocarcinogenesis, we induced hepatocellular carcinoma (HCC) in wild type (wt) and CHOP knockout (KO) mice usin... CXCL1 (CXC chemokine-ligand-1) is a ligand for CXC chemokine receptor 2 expressed on hepatic stellate cells (HSC). Nebulized lidocaine in the treatment of intractable cough. 2019 Nov;11(11):4663-4670. doi: 10.21037/jtd.2019.10.59. To investigate the added value of gadoxetic acid-enhanced MRI in monitoring liver function and disease progression in patients with primary sclerosing cholangitis (PSC). , Infectious HCV particles bind to host lipoproteins such as low-density lipoproteins (LDL). It is therefore not surprising that in current Endobronchial administration of local anesthetics such as lidocaine is often used for cough suppression during bronchoscopy. (DOC), Proportion of each ethnic group with the genotype that predicts treatment failure: HLA-C2C2 homozygotes and IL28B G carriers. © 2008-2021 ResearchGate GmbH. Tobias MÜLLER | Cited by 5,016 | of University of Leipzig, Leipzig | Read 150 publications | Contact Tobias MÜLLER University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. Ziele & Methoden: Wir bestimmten die PSC-IgG4 Pravalenz in zwei grosen unabhangi... To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. Join ResearchGate to find the people and research you need to help your work. Chronic hepatitis C virus infection is associated with a significant health burden. TOBIAS MÜLLER Peuckert, Mehring open and accessible to wider, younger audiences as well as augmenting the concert experience as a whole. This site needs JavaScript to work properly. Andhim â new boys in town It was spring 2010 when the cologne natives decided to kick their ass into gear and get out of their Studio to bring their beats to the world. (DOC), Summary of associations between SNPs in Aim: (DOC), Association of HLA-C inhibitory receptor genes KIR2DL2 and KIR2DL3 on viral clearance with and without therapy in combination with HLA-C genotypes. To investigate the tolerability of nebulized lidocaine compared to conventional lidocaine administration via syringe through the working channel of the bronchoscope in patients undergoing bronchoscopy. We, therefore, investigated the use, effectiveness, and tolerability of DAAs in patients wi... Background Zusammenfassung Lung India. Here, we investigated whether the CXCL1 rs4074 polymorphism affects CXCL1 expression and progression of chronic hepatitis C virus (HCV) infection towards cirrhosis. Thus, CXCL1 might contribute to HSC activation and fibrogenesis. Less than 12 months later Andhim were voted in the top-ten German newcomers of Groove and Raveline Magazine and their records were found in the cases and remix-wishes of many unknown and famous DJâs alike. Drug Des Devel Ther. Prevention and treatment information (HHS). The overall aim of my research is to gain a better understanding of our body’s natural defense mechanisms against viruses, which may help us to eventually develop new antiviral therapies. Thus, CXCL1 might contribute to HSC activation and fibrogenesis. Methods: The randomized trial took place in two urban hospitals in Germany. The presence of baseline resistance‐associated substitutions (RASs) reduced sustained virologic response (SVR) rates in chronic hepatitis C virus (HCV) genotype 1a infected patients treated with Elbasvir/Grazoprevir (EBR/GZR). However, it remains unclear how to respond to a detectable or even quantifiable HCV RNA result. At Oregon State Treasury, we prioritize long-term thinking, prudent financial management, and resources to help Oregonians invest in themselves and their families. Abstract. derstandard.at. Tobias Müller Bilateral severe vision loss is a dramatic illness that requires extended diagnostics and immediate therapy. This polar guanosine analog improves the sustained virological response (SVR) rates, but may induce hemolytic anemia. Bethesda, MD 20894, Copyright We wanted to determine whether inappropriate innate immune respons... HCV-Tg mice: HCV-Tg and control mice were sacrificed, liver excised and protein extracted and assessed for HCV-Core protein by western blotting. HCV proteins core and NS3 can bind to toll-like receptor 2 (TLR2) and trigger inflammatory responses. Respir Res. Celebrate and remember the lives we have lost in Oregon. In the remaining 70% the infection persists, causing chronic liver inflammation and disease. Financial Empowerment. Polymorphisms in the TLR2 gene predispose to various forms of malignancy but have not been studied in HCV-associated HCC. Purpose: This trial investigated the effect of a stroke support service on physical functioning in post-stroke outpatients. The visualizations for "Tobias Müller, Großholbach, Germany" are provided by North Data and may be reused under the terms of the Creative Commons CC-BY license. ER stress and JNK phosphorylation are induced in HCV infected cells: Infected and non-infected HuH7.5.1 cells were grown in parallel under the same conditions of nutrient supply and cell density. Einleitung In Deutschland sind mehr als 250 000 Patienten an einer chronischen Hepatitis C (CHC) erkrankt. Treasurer Tobias Read. Thirty patients were included, 15 in each group. (DOC), Association of HLA-C inhibitory receptor genes KIR2DL2 and KIR2DL3 on viral clearance in combination with HLA-C genotypes based on two-digit genotyping. (DOC), Association of HLA-C activating receptor genes KIR2DS1 and KIR2DS2 on viral clearance with and without therapy in combination with HLA-C genotypes. CYP2R1 (DOC), Linkage disequilibrium of SNPs in 2018 Nov 21;19(1):227. doi: 10.1186/s12931-018-0926-5. Summary: ProfDist is a user-friendly software package using the profile-neighbor-joining method (PNJ) in inferring phylogenies based on profile distances on DNA or RNA sequences. Low-density lipoprotein receptors have been termed candidate receptors for HCV-LDL complexes. Methods: doi: 10.4103/lungindia.lungindia_108_19. The genetic background of alcoholic liver diseases and their complications are increasingly recognized. We investigated if this polymorphism may... Unlabelled: Tobias MÜLLER | Cited by 2,487 | of University Hospital RWTH Aachen, Aachen | Read 101 publications | Contact Tobias MÜLLER Careers. This stress induces a cyto-protective signaling cascades termed the unfolded protein response (UPR) aimed at restoring homeostasis. HuH7.5.1 hepatoma cells were infected with the HCV-JFH1 virus. (DOC), Association of IL28B rs8099917 genotypes with viral clearance with and without therapy. Among patients newly infected with hepatitis C virus (HCV), only 20-30% clear the infection spontaneously. The German HCV (1b)-contaminated anti-D cohort provides an ideal population to investigate the natural course of HCV infection in a large, homogenous cohort of young women from the date of HCV inoculation. Nebulized lidocaine alone or combined with fentanyl as a premedication to general anesthesia in spontaneously breathing pediatric patients undergoing rigid bronchoscopy. This study aimed to evaluate the frequency of NS5A RASs and treatment outcomes in patients for whom EBR/GZR... Data on the prevalence of resistance‐associated substitutions (RASs) and their implications for treatment with direct acting antivirals (DAAs) is sparse in European patients with HCV genotype 4. Endpoints were consumption of lidocaine and sedative drugs, as well as patient tolerance and safety. tobmueller@ukaachen.de. Functional host genetic single nucleotide polymorphisms (SNPs) in the APOE gene encoding apolipoprotein E (apoE) - a major structural LDL compone... Background: An exception is in the treatment of chronic hepatitis C virus (HCV) genotype 1 infection with pegylated interferon-alpha and ribavirin (PegIFN/R). A T-helper (Th) 2 cell cytokine profile predominates in liver tissues from these patients. Tobias Miller was born on 2 January 1776, in Cambria, Pennsylvania, United States as the son of Christian Miller and Christina Elizabeth Solomnsmiller. Tobias Müller is on Facebook. Kim JE, Min SK, Chae YJ, Lee YJ, Moon BK, Kim JY. investigated in the present study. Samples of 195 genotype 4‐... PurposeTo differentiate subtypes of hepatocellular adenoma (HCA) based on enhancement characteristics in gadoxetic acid (Gd-EOB) magnetic resonance imaging (MRI).Materials and methodsForty-eight patients with 79 histopathologically proven HCAs who underwent Gd-EOB-enhanced MRI were enrolled (standard of reference: surgical resection). This study investigated clinical and epidemiologic characteristics of elderly HCV-infected patients as well as the ef... Background & Aims We evaluated whether the interplay of both IFNL3 polymorphisms rs12979860 and rs809... Primers for SNP genotyping assays. Vergleichbare europaische Daten existieren bisher nicht. Aims: To investigate the prevalence of elevated IgG4 levels and to compare prognosis between patients with and without elevated IgG4 levels in serum in two European cohorts of pat... Unlabelled: Join ResearchGate to contact this researcher and connect with your scientific community. FOIA Muscarinic acetylcholine receptor type 3 (mAChR3)-mediated signaling might be involved in the pathogenesis of chronic inflammatory biliary diseases such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). View Laszlo Tobiasâ profile on LinkedIn, the worldâs largest professional community. (b) Association of combinations of IL28B SNP rs12979860 and HLA-C genotypes on viral clearance with therapy. Based on several standard modules, our turnkey solutions serve many busines cases from R&D to volume production, enabling a fast time to market & optimized TCO. Background: January 22, 2017. Müller T, Cornelissen C, Dreher M. Nebulization versus standard application for topical anaesthesia during flexible bronchoscopy under moderate sedation - a randomized controlled trial. Long-term consequences are the development of liver cirrhosis and hepatocellular carcinoma. DHCR7 2019 May 27;13:1835-1841. doi: 10.2147/DDDT.S201416. He married Anna Miller on 16 June 1800. 2020 Jul;21(4):223-227. doi: 10.5152/TurkThoracJ.2019.19016. Would you like email updates of new search results? RNA and protein were extracted on the indicated times and assessed for (b) HCV RNA (c) NS5A by real-time PCR and western blotting respectively. Facebook gives people the power to share and makes the world more open and connected. Epidemiological data has only been provided from tertiary centres. (TIF). IgG4-related cholangitis is a chronic inflammatory biliary disease that involves different parts of the pancreatobiliary system, but little is known about its mechanisms of pathogenesis. Epub 2012 Nov 28. Tight control of PRR signalling provides tolerance to physiological amounts of intestinal endotoxins in human bile to avoid constant innate immune activation in BECs. 6,076 likes. Mohan A, Madan K, Hadda V, Tiwari P, Mittal S, Guleria R, Khilnani GC, Luhadia SK, Solanki RN, Gupta KB, Swarnakar R, Gaur SN, Singhal P, Ayub II, Bansal S, Bista PR, Biswal SK, Dhungana A, Doddamani S, Dubey D, Garg A, Hussain T, Iyer H, Kavitha V, Kalai U, Kumar R, Mehta S, Nongpiur VN, Loganathan N, Sryma PB, Pangeni RP, Shrestha P, Singh J, Suri T, Agarwal S, Agarwal R, Aggarwal AN, Agrawal G, Arora SS, Thangakunam B, Behera D; Jayachandra, Chaudhry D, Chawla R, Chawla R, Chhajed P, Christopher DJ, Daga MK, Das RK, D'Souza G, Dhar R, Dhooria S, Ghoshal AG, Goel M, Gopal B, Goyal R, Gupta N, Jain NK, Jain N, Jindal A, Jindal SK, Kant S, Katiyar S, Katiyar SK, Koul PA, Kumar J, Kumar R, Lall A, Mehta R, Nath A, Pattabhiraman VR, Patel D, Prasad R, Samaria JK, Sehgal IS, Shah S, Sindhwani G, Singh S, Singh V, Singla R, Suri JC, Talwar D, Jayalakshmi TK, Rajagopal TP. Conclusion: (TIF). This study investigated RASs before and after DAA failure in different genotype 4 subtypes and evaluated retreatment efficacies. Tobias Muellers, of Wisconsin-Platteville, pole vaults while competing in the Hep during the Division III Men's and Women's Indoor Track & Field Championships held at the Birmingham CrossPlex on... Get premium, high resolution news photos at Getty Images The aim of this study was to clarify the role of... Background & aims: DER STANDARD. It is a tool for reconstructing and visualizing large phylogenetic trees providing new and standard features with a special focus on time efficency, robustness and accuracy. Progress can only be measured in relation to the goal and the point dâappuis. , and (DOC), Association of HLA-C activating receptor genes KIR2DS1 and KIR2DS2 on viral clearance with and without therapy. J Anesth. (DOC), (a) Association of combinations of IL28B SNP rs8099917 and HLA-C genotypes on viral clearance with and without therapy. NTPDase2 has protective properties in liver fibrosis and may impact bile duct epithelial turnover. 8600 Rockville Pike BLE, WiFi, Cellular, LoRaWAN and more. ... Tobias Müller - 23 Sep 2015. Käsknöpfle: Der Käse entscheidet. -Effects of Local Anesthetics on Smooth Muscle Tissue in Rat Trachea: An In Vitro Study. COVID-19 is an emerging, rapidly evolving situation. JOHN D. SKJERVEM CHIEF INVESTMENT OFFICER INVESTMENT DIVISION PHONE 503-431-7900 FAX 503-620-4732 STATE OF OREGON OFFICE OF THE STATE TREASURER 16290 SW UPPER BOONES FERRY ROAD TIGARD, OREGON 97224 OREGON INVESTMENT COUNCIL SEPTEMBER 20, 2017 MEETING MINUTES Members Present: Rukaiyah Adams, Tobias Read, ⦠Chemokines play important roles in HCV-induced liver fibrosis. Nebulization versus standard application for topical anaesthesia during flexible bronchoscopy under moderate sedation - a randomized controlled trial. The aim of this study was to anal... Background & aims: (DOC). Privacy, Help Join Facebook to connect with Tobias Müller and others you may know. In addition, there were no between-group differences in patient tolerance or safety (all p > 0.05). Ecosystem. OBJECTIVE: (DOC), The distribution of the six common IL28B haplotypes bound by SNPs rs12980275 and rs8099917. (DOC). Dozens of leading companies trust Mbed OS. Viral clearance is achieved in 40%-50% of patients. We therefore retrospectively included 40 HCAs c... Ecto-nucleotidase triphosphate diphosphohydrolase-2 (NTPDase2) is an ecto-enzyme that is expressed on portal fibroblasts in the liver that modulates P2 receptor signaling by regulating local concentrations of extracellular ATP and ADP. IL28B gene polymorphism is the best baseline predictor of response to interferon alfa-based antiviral therapies in chronic hepatitis C. Recently, a new IFN-L4 polymorphism was identified as first potential functional variant for induction of IL28B expression. Hepatitis C virus (HCV) uses several host factors to infect and replicate in human hepatocytes. (DOC), Association of HLA-C inhibitory receptor genes KIR2DL2 and KIR2DL3 on viral clearance with and without therapy. Am J Hosp Palliat Care. standard deviation: max drawdown: Are you Tobias Mueller? In dieser Arbeit werden die Veränderungen der Baselinecharakteristika von 17 093 HCV-Patienten mit Genotyp 1a/1b, die im Zeitraum 2004–2018 in Deutschland antiviral therapiert wurden, analysiert. 2013 May;23(5):429-34. doi: 10.1111/pan.12081. Only verified researchers can join ResearchGate and send messages to other members. To achieve a better distribution of lidocaine in the tracheobronchial tree, spray catheters have been developed, allowing nebulization of the local anesthetic solution. The natural course of HCV infection remains controversial. IRCCS Ospedale Casa Sollievo della Sofferenza, University Medical Center Hamburg - Eppendorf, Institut für Interdisziplinäre Medizin Hamburg, Klinik für Allgemein-, Viszeral- und Gefäßchirurgie, Klinik für Allgemein- Viszeral- und Transplantationschirurgie, Dept. National Library of Medicine The standard of hepatitis C antiviral therapy combines pegylated interferon-α with ribavirin. In the present study, we investigated the influence of the CXCL1 rs4074 polymorphism on the occurrence of alcohol induced liver cirrhosis and hepatocellular carcinoma (HC... Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the most powerful predictors for sustained virologic response (SVR) in patients with chronic hepatitis C virus (HCV) infection, compared to other biochemical or histological baseline parameters. 2019 Jul-Aug;36(4):288-294. doi: 10.4103/lungindia.lungindia_348_18. Our partners. Investigating the evolution of the DAA utilization patterns and treatment outcomes could... Background: Chronic hepatitis C virus (HCV) infection is a major risk factor for hepatocellular carcinoma (HCC). Hillsboro Arts & Crafts Fair, Hillsboro, Kansas. Results: Evaluation of Muscarinic Acetylcholine Receptor Type 3 Gene Polymorphisms in Patients with Primary Biliary Cholangitis and Primary Sclerosing Cholangitis, Real World Experience of Prescribing Tenofovir Alafenamide for Chronic Hepatitis B Patients in Germany, Assoziation des Polymorphismus rs7000921 im INTS10-Gen mit der Leberzirrhose bei kaukasischen Patienten mit chronischer Hepatitis B, Wirksamkeit und Sicherheit einer Sofosbuvir-Monotherapie bei Patienten mit chronischer Hepatitis E-Die HepNet SofE Studie, Persistenz von HCV Resistenz-assoziierten Substitutionen in NS3, NS5A und NS5B nach einem DAA Therapieversagen, Evolution of HCV patient characteristics and DAA regimens in the German Hepatitis C Registry (DHC-R) in 2014 and 2015, PS-179-Analysis of long-term persistence of HCV resistance-associated substitutions within NS, NS5A and NS5B in genotype 1 and 3 after DAA treatment failure, LBO-04-Efficacy and safety of sofosbuvir monotherapy in patients with chronic hepatitis E-The HepNet SofE pilot study, Hepatitis C therapy with direct antiviral agents in patients with advanced chronic kidney disease: real-world experience of the German Hepatitis C-Registry (Deutsches Hepatitis C-Register), Alcohol and Cannabis Consumption Does Not Diminish Cure Rates in a Real-World Cohort of Chronic Hepatitis C Virus Infected Patients on Opioid Substitution Therapy—Data From the German Hepatitis C-Registry (DHC-R), Deutsches Hepatitis C-Register (DHC-R) – eine Zwischenbilanz 4 Jahre nach Zulassung direkt antiviraler Substanzen (DAAs), Outcomes and costs of treating hepatitis C patients with second-generation direct-acting antivirals: results from the German Hepatitis C-Registry, Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry, Die Auswirkung frühzeitiger Corticosteroidtherapie bei Patienten mit unklarer akuter Hepatitis, Clinical significance of detectable and quantifiable HCV RNA at the end of treatment with ledipasvir/sofosbuvir in GT1 patients, Impact of early corticosteroid treatment in patients with indeterminate acute severe hepatitis, Charakteristische ALT Verläufe nach Steroid Reduktion bei akuter Hepatitis ermöglichen eine Differenzierung von AIH und DILI, Serum IgG4 and long term outcome in patients with primary biliary cholangitis treated with ursodeoxycholic acid, Apolipoprotein E (APOE) allele frequencies in chronic and self-limited hepatitis C suggest a protective effect of APOE4 in the course of HCV infection, Einfluss des Apolipoprotein E Polymorphismus auf den Verlauf der Hepatitis C Virus (HCV) Infektion, Keratin-8-Mutationen prädisponieren nicht zur Entwicklung chronischer Lebererkrankungen insbesondere nicht zur kryptogenen Cirrhose, Predictive Value of Interferon-Lambda Gene Polymorphisms for Treatment Response in Chronic Hepatitis C, Validierung etablierter International Autoimmune Hepatitis Group (IAIHG) Diagnose-Scores in 246 Patienten mit gut charakterisierter autoimmuner Hepatitis in einer deutschen Universitätsklinik, The impact of elevated serum IgG4 levels in patients with primary sclerosing cholangitis, Polymorphisms in Melanoma Differentiation-Associated Gene 5 Link Protein Function to Clearance of Hepatitis C Virus, A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease, Evaluation of Liver Disease Progression in the German Hepatitis C Virus (1b)-Contaminated Anti-D Cohort at 35 Years After Infection, CCAAT/Enhancer-Binding Protein Homologous (CHOP) Protein Promotes Carcinogenesis in the DEN-Induced Hepatocellular Carcinoma Model, Influence of the CXCL1 rs4074 A Allele on Alcohol Induced Cirrhosis and HCC in Patients of European Descent, Association of IFNL3 rs12979860 and rs8099917 with Biochemical Predictors of Interferon Responsiveness in Chronic Hepatitis C Virus Infection, Assoziation zwischen IFNL3 Polymorphismen und klinischen Prädiktoren des Ansprechens auf eine interferon-basierte antivirale Therapie bei chronischer Hepatitis C, CCR5-Δ32 genotype does not improve predictive value of IL28B polymorphisms for treatment response in chronic HCV infection, Increased T-Helper 2 Cytokines in Bile From Patients With IgG4-Related Cholangitis Disrupt the Tight Junction-Associated Biliary Epithelial Cell Barrier, Untersuchungen zur Bedeutung erhöhter IgG4 Serumspiegel in zwei großen unabhängigen europäischen Kohorten mit 345 Patienten mit primär sklerosierender Cholangitis (PSC), A Genetic Validation Study Reveals a Role of Vitamin D Metabolism in the Response to Interferon-Alfa-Based Therapy of Chronic Hepatitis C, Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection, Hepatocytes That Express Variants of Cyclophilin A Are Resistant to HCV Infection and Replication, 912 APOLIPOPROTEIN E4 ALLELE PROTECTS FROM CHRONIC HCV INFECTION, The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C, TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients, The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients, The PNPLA3 rs738409 148M/M Genotype Is a Risk Factor for Liver Cancer in Alcoholic Cirrhosis but Shows No or Weak Association in Hepatitis C Cirrhosis, Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis, HCV Causes Chronic Endoplasmic Reticulum Stress Leading to Adaptation and Interference with the Unfolded Protein Response, IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study, TH2 Zytokine wie IL-4 und IL-13 beeinträchtigen die Barrierefunktion und die Wundheilung humaner biliärer Epithelzellen (BECs), Kombination von IL28B Varianten (SNPs rs12979860 und rs8099917) verfeinert die Vorhersage für ein dauerhaftes Therapieansprechen bei chronischer Hepatitis C Virus (HCV)-Infektion, 232 TRAIL RECEPTOR I POLYMORPHISMS C626G AND A638C ARE ASSOCIATED WITH AN INCREASED RISK FOR THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA (HCC) IN HCV-INFECTED PATIENTS, 1304 TH2 CYTOKINE-MEDIATED BILIARY EPITHELIAL CELL (BEC) BARRIER DYSFUNCTION MAY CONTRIBUTE TO IMMUNOGLOBULIN G4 (IGG4) ASSOCIATED SCLEROSING CHOLANGITIS (IAC), 1157 NUCLEOSIDE TRANSPORTER SLC28A2/3 AND SLC29A1/2 GENETICS: PROTECTION AGAINST ANAEMIA IN CHRONIC HEPATITIS C PATIENTS RECEIVING RIBAVIRIN, 1358 DISTINCT, ALCOHOL-MODULATED EFFECTS OF PNPLA3 GENOTYPE ON PROGRESSION OF CHRONIC HEPATITIS C, Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients, A Duffy antigen receptor for chemokines (DARC) polymorphism that determines pro-fibrotic chemokine serum concentrations is not directly associated with severity of hepatitis C infection, Distinct, alcohol-modulated effects of PNPLA3 genotype on progression of chronic hepatitis C, Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy, Prognose Untersuchungen zum Langzeitverlauf der primär sklerosierenden Cholangitis (PSC), Bedeutung von IL28B Gen Polymorphismen bei Hepatitis C Virus Genotyp 2 und 3 infizierten Patienten, Gestörte Endotoxin Toleranz in Gallengangsepithelien bei Patienten mit fortgeschrittener primär sklerosierender Cholangitis (PSC), Prävalenz erhöhter Immunglobulin G4 (IgG4) Konzentrationen bei Patienten mit chronisch-entzündlichen Lebererkrankungen unterschiedlicher Ätiologie, Innate barriers of respiratory virus infections, Department of General, Visceral and Transplantation Surgery.
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